Marc Gielen

Initially trained as an Engineer from the Ecole Centrale Paris, I then pursued a PhD in Neurobiology at the Ecole Normale Superieure (2005-2009). Since then, my research has focused on the structure-function properties of neuronal ligand-gated ion channels, which are involved in many physiological and pathological conditions such as epilepsy, anxiety, schizophrenia, autism and neurodegenerative diseases.
Still, I am convinced that tomorrow's therapeutic advances in neurology and psychiatry will only be attained by combining both an in-depth biological expertise with a broader perspective on the pathologies' impact and patient care. This is the reason why I have decided to enroll in Medical School at Sorbonne Université starting in 2018.

5 main publications :
● Gielen M.°, Barilone N., Corringer P.J., 2020. The desensitization pathway of GABAA receptors, one subunit at a time. Nature Communications,11(1):5369. °auteur correspondant
● Gielen M.°, Thomas P., Smart T.G.°, 2015. The desensitization gate of inhibitory Cys-loop receptors. Nature Communications, 6:6829 doi: 10.1038/ncomms7829. °auteur co-correspondant
● Gielen M.°, Lumb M.J., Smart T.G.°, 2012. Benzodiazepines modulate GABAA receptors by regulating the preactivation step following GABA binding. The Journal of Neuroscience, 32(17):5707-15. °auteur co-correspondant
● Gielen M., Siegler Retchless B., Mony L., Johnson J.W., Paoletti P., 2009. Mechanism of differential control of NMDA receptor activity by NR2 subunits. Nature, 459(7247):703-7.
Highlighted in Faculty Opinions: https://facultyopinions.com/prime/1160347
● Gielen M., Le Goff A., Stroebel D., Johnson J.W., Neyton J., Paoletti P., 2008. Structural rearrangements of NR1/NR2A NMDA receptors during allosteric inhibition. Neuron, 57(1):80-93.